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Above is the original artwork (pen/brush and ink with graphite on illustration board) for a Mutt and Jeff comic strip which was originally published by the Wheeler/Bell Syndicate on December 22, 1922. A noteworthy thing about this drawing is that it's HUGE, 11.25" x 30". Typically, drawings for daily strips are about 8" x 20", and I have no idea why M&J strips from this period were drawn so large; it's not like the drawings are particularly complicated, refined, or detailed.
Bud Fisher created A. Mutt (the feature's original title) in 1907, and it is generally regarded as being the first successful daily comic strip. Fisher became very, very rich thanks to Mutt and Jeff, but quickly lost interest in actually drawing it. By the time the above drawing was published, all the work was done by Billy Liverpool and Ed Mack (who probably drew this one), but that didn't stop Fisher, a notorious credit grabber, braggart and all-around asshole, from signing it! A good example of Fisher's hubris is that he liked to claim in interviews that he drew every frame of the 300-or-so M&J animated cartoons produced by the Barré Studio, an absolutely ludicrous and insulting claim which surely endeared him to the talented production artists who slaved away to make him even wealthier.
This drawing has been through some rough times (I'm sure its awkward size didn't help): it got bent up and mangled on the left and re-flattened, probably with an iron; it has moisture damage, and at some point in 1923 it was reformatted for publication elsewhere, hence the second pasted-on signature and copyright notice.
I love this strip, though. So many question marks! It features one of my favorite things, a vaudeville-style prohibition gag (a subject I always favor; I've got four or five other prohibition-themed strips from the 20s in my collection). The title of this episode, written in pencil at the top, is "You Can't Tell What You're Drinking These Days", and that's the key to the gag*: the judge asks what they were drinking, and hell if they know what sort of bathtub concoction it was. In the end, it's clear that Mutt and Jeff really need to work on their negotiating skills.
*Comic strips in the early days usually carried titles, a tradition which petered out and then was finally done away with when comics shrank in the 40s. Later, Bill Griffith revived the practice in Zippy the Pinhead.